Standard Mechanical Milling: A Cost-Effective and Scalable Process

Standard mechanical milling is an ideal process for reducing the particle size of powders without requiring specific configurations. This versatile method is particularly suited for products characterised by a high melting point (above 200°C), good flowability, and a high dosage prescription indicative of low pharmacological activity.

Our approach, utilising large grid holes with hammer mills or Quadro Co-mills, or selecting medium/low rotor speeds for pin mills, meticulously prevents undesirable temperature increases, thereby preserving the powder’s integrity.

Rotor Speed: governs the energy applied to fragment particles, generating smaller sizes.

Feed Rate: determines the amount of powder within the mill chamber, influencing the required milling energy.

Grid Hole Diameter: controls the residence time of the powder within the mill chamber. Decreasing this diameter increases the probability of particles undergoing further size reduction due to multiple collisions with milling tools (e.g., hammers, blades, or various impeller types).

Mechanical milling under standard conditions offers several significant advantages. It consistently achieves a tight Particle Size Distribution (PSD) typically ranging from 50 to 150 microns, even when operating under demanding conditions. This process efficiently reduces particle size, substantially improves powder flowability, and increases surface area, leading to enhanced product performance and functionality. Furthermore, it represents a cost-effective and scalable method for manufacturing a wide range of products, including critical pharmaceuticals.